Academic Surgical Unit, University of Hull, Cottingham, HU16 5JQ, UK.
Langenbecks Arch Surg. 2012 Oct;397(7):1053-7. doi: 10.1007/s00423-012-0986-9. Epub 2012 Aug 9.
Lymph node ratio (LNR) has been shown to be an independent prognostic factor in stage III colorectal cancer. Abdominoperineal resection (APR) of rectum is historically associated with poorer oncological outcomes compared to other colorectal resections, and significance of LNR in this group of patients has not been studied.
Our aim was to determine impact of LNR on oncological outcomes in a series of patients with rectal cancers undergoing APR.
A series of patients who had undergone APR and had lymph node metastasis were identified from a prospectively maintained clinical, histopathological and radiological database. LNR was calculated, and Cox regression was used to determine the impact of factors affecting local recurrence, distal metastases and overall survival.
Fifty-eight (42 males) patients were identified to have rectal cancer with lymph node involvement. LNR was an independent predictor of distal metastasis and overall survival at cutoff levels of 0.17, 0.41 and 0.69.
Lymph node ratio is an independent predictor of survival outcomes in patients with stage III tumours undergoing APR. LNR may help improve stratification of this group of patients.
淋巴结比率（LNR）已被证明是 III 期结直肠癌的独立预后因素。与其他结直肠切除术相比，腹会阴切除术（APR）历史上与较差的肿瘤学结果相关，并且 LNR 在这组患者中的意义尚未得到研究。
我们的目的是确定 LNR 在接受 APR 的直肠腺癌患者系列中的肿瘤学结果中的影响。
从前瞻性维护的临床、组织病理学和影像学数据库中确定了接受 APR 且有淋巴结转移的一系列患者。计算 LNR，并使用 Cox 回归确定影响局部复发、远端转移和总生存期的因素的影响。
确定 58 名（42 名男性）患者患有有淋巴结受累的直肠腺癌。LNR 是远处转移和生存的独立预测因子，截断值分别为 0.17、0.41 和 0.69。
LNR 是接受 APR 的 III 期肿瘤患者生存结果的独立预测因子。LNR 可能有助于改善这组患者的分层。
