Ellison M J, Horner R D, Willis S E, Cummings D M
Department of Family Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Pharmacotherapy. 1990;10(6):383-6.
This clinical study assessed the influence of pentoxifylline and its metabolites on steady-state serum theophylline concentrations. Nine healthy volunteers took sustained-release formulations of pentoxifylline, theophylline, and a combination of both agents each for 7 days at standard therapeutic doses in a randomized order. Serum theophylline concentrations were analyzed using fluorescence-polarization immunoassay (TDx) technique. During the pentoxifylline treatment phase, serum theophylline concentrations were undetectable, demonstrating the lack of assay interference from pentoxifylline and its metabolites. Mean trough steady-state serum theophylline concentrations were 30% higher (p less than 0.05) during the combination treatment phase compared to theophylline administration alone, and varied considerably. Although side effects were more frequent during the combination phase, differences in the number of adverse reactions did not achieve statistical significance. This study demonstrates an interaction between theophylline and pentoxifylline, and indicates that close monitoring of serum theophylline concentrations during combination therapy is warranted.
这项临床研究评估了己酮可可碱及其代谢产物对稳态血清茶碱浓度的影响。9名健康志愿者以随机顺序，按标准治疗剂量分别服用己酮可可碱、茶碱以及两者的复方制剂，各服用7天。采用荧光偏振免疫分析（TDx）技术分析血清茶碱浓度。在己酮可可碱治疗阶段，血清茶碱浓度检测不到，表明己酮可可碱及其代谢产物不存在检测干扰。与单独使用茶碱相比，联合治疗阶段的平均谷值稳态血清茶碱浓度高30%（p<0.05），且差异较大。虽然联合治疗阶段副作用更频繁，但不良反应数量的差异未达到统计学意义。本研究证明了茶碱与己酮可可碱之间存在相互作用，并表明在联合治疗期间有必要密切监测血清茶碱浓度。
