Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem Jerusalem, Israel.
Front Immunol. 2012 Aug 2;3:238. doi: 10.3389/fimmu.2012.00238. eCollection 2012.
Mast cells (MC) are major participants in the allergic reaction. In addition they possess immunomodulatory roles in the innate and adaptive immune reactions. Their functions are modulated through a number of activating and inhibitory receptors expressed on their surface. This review deals with some of the most recently described receptors, their expression patterns, ligand(s), signal transduction mechanisms, possible cross-talk with other receptors and, last but not least, regulatory functions that the MC can perform based on their receptor expression in health or in disease. Where the receptor role on MC is still not clear, evidences from other hematopoietic cells expressing them is provided as a possible insight for their function on MC. Suggested strategies to modulate these receptors' activity for the purpose of therapeutic intervention are also discussed.
肥大细胞（MC）是过敏反应的主要参与者。此外，它们在先天和适应性免疫反应中具有免疫调节作用。它们的功能通过其表面表达的许多激活和抑制受体来调节。本综述涉及一些最近描述的受体，它们的表达模式、配体（s）、信号转导机制、与其他受体的可能串扰以及最后但并非最不重要的是，基于其在健康或疾病状态下的受体表达，MC 可以执行的调节功能。对于 MC 上的受体作用仍不清楚的地方，提供了来自表达这些受体的其他造血细胞的证据，作为其在 MC 上的功能的可能见解。还讨论了为治疗干预目的调节这些受体活性的建议策略。
