Dangi-Garimella Surabhi, Krantz Seth B., Shields Mario A., Grippo Paul J., Munshi Hidayatullah G.
Division of Hematology/Oncology, Department of Medicine
Division of Surgical Oncology Department of Surgery, Feinberg School of Medicine, Northwestern University;
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most lethal human malignancies, with median survival of less than one year and overall 5-year survival of less than 5%. There is increasing evidence for contribution of epithelial- mesenchymal transition (EMT) to pancreatic cancer metastasis and to treatment resistance. In this chapter we will review the role of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and detail the role of EMT in modulating resistance of PDAC cells to drug therapies. Finally, we will identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer
胰腺导管腺癌（PDAC）仍然是最致命的人类恶性肿瘤之一，中位生存期不到一年，总体5年生存率不到5%。越来越多的证据表明上皮-间质转化（EMT）在胰腺癌转移和治疗耐药中发挥作用。在本章中，我们将综述EMT在胰腺癌进展中的作用，特别关注参与EMT的转录因子和微小RNA。我们将研究EMT如何参与干细胞的产生和维持，并详细阐述EMT在调节PDAC细胞对药物治疗耐药性中的作用。最后，我们将确定可能有助于降低胰腺癌相关发病率和死亡率的潜在EMT靶向药物。
