ZnI2 和 FeCl3 介导的唑啉和唑的简便、选择性和区域控制合成。
Facile, selective, and regiocontrolled synthesis of oxazolines and oxazoles mediated by ZnI2 and FeCl3.
机构信息
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Org Lett. 2012 Sep 7;14(17):4478-81. doi: 10.1021/ol301980g. Epub 2012 Aug 9.
PMID:22876973
Abstract
An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI(2) and FeCl(3) is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.
摘要
一种由 ZnI(2) 和 FeCl(3) 介导的 2-恶唑啉和 2-恶唑选择性和区域控制合成的简便方法被描述。在温和的反应条件下，各种官能团的炔酰胺的 Lewis 酸促进环化反应得到 2-恶唑啉和 2-恶唑，产率良好至优秀。
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