Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
Org Lett. 2012 Sep 7;14(17):4478-81. doi: 10.1021/ol301980g. Epub 2012 Aug 9.
An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI(2) and FeCl(3) is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.
一种由 ZnI(2) 和 FeCl(3) 介导的 2-恶唑啉和 2-恶唑选择性和区域控制合成的简便方法被描述。在温和的反应条件下，各种官能团的炔酰胺的 Lewis 酸促进环化反应得到 2-恶唑啉和 2-恶唑，产率良好至优秀。
