Division of Endocrinology, Diabetes and Metabolism, Chiba University Hospital, 1-8-1 Inohana, Chiba-shi, Chiba 260-8670, Japan.
Endocrinol Metab Clin North Am. 2012 Sep;41(3):557-69. doi: 10.1016/j.ecl.2012.04.003. Epub 2012 May 22.
Vitamin D is important for the normal development and maintenance of bone. The elucidation of the vitamin D activation pathway and the cloning of the vitamin D receptor have advanced our understanding of the actions of vitamin D on bone. The preponderance of evidence indicates that 1,25(OH)₂D₃ enhances bone mineralization through its effects to promote calcium and phosphate absorption. Although 1,25(OH)₂D₃ stimulates bone resorption in vitro, treatment in vivo can prevent bone loss and fracture through several potential mechanisms. The development of vitamin D analogues has provided new therapeutic options for increasing bone mineral density and reducing fractures.
维生素 D 对骨骼的正常发育和维持至关重要。维生素 D 激活途径的阐明和维生素 D 受体的克隆，增进了我们对维生素 D 对骨骼作用的理解。大量证据表明，1,25(OH)₂D₃ 通过促进钙和磷吸收来增强骨矿化。虽然 1,25(OH)₂D₃ 在体外刺激骨吸收，但在体内治疗可以通过几种潜在机制预防骨丢失和骨折。维生素 D 类似物的开发为增加骨密度和减少骨折提供了新的治疗选择。
