Miranda-Ruiz R, Castañón-González J, Pérez Aldana C, Arias E, Díaz de León Ponce M, Zárate A
Unidad de Investigación de Endocrinología, IMSS, México, D.F.
Rev Gastroenterol Mex. 1990 Apr-Jun;55(2):67-9.
The effect of treatment with a long acting analogue of somatostatin (SMS 201-995) administered by subcutaneous route 165 micrograms every eight hours in a patient with a external biliary fistula is reported. There was a significant reduction of the daily fistula output during treatment when compared with the basal periods (p = 0.04), with an average decrease of 270 ml/day during the first period of treatment and 357 ml/day when the drug was administered the second time (p = 0.04). There where not changes in the chemical composition of the bile neither adverse side effects were observed during treatment. These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.
报告了对一名患有外胆道瘘的患者每八小时皮下注射165微克长效生长抑素类似物（SMS 201-995）的治疗效果。与基础期相比，治疗期间瘘管每日排出量显著减少（p = 0.04），在治疗的第一阶段平均每日减少270毫升，第二次给药时平均每日减少357毫升（p = 0.04）。治疗期间胆汁的化学成分没有变化，也未观察到不良反应。这些结果表明，SMS 201-995可能对外胆道瘘的治疗有用。
