State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, People's Republic of China.
J Agric Food Chem. 2012 Sep 5;60(35):8544-51. doi: 10.1021/jf302746m. Epub 2012 Aug 23.
On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1-12 and 18-50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 19 and 27 displayed higher activity than commercial Ribavirin, thus emerging as potential inhibitors of plant virus. The novel concise structure provides another new template for antiviral studies.
基于我们之前的结构-活性关系（SAR）和抗病毒机制研究，我们设计了一系列基于菲的安托芬衍生物（1-12 和 18-50），针对烟草花叶病毒（TMV）RNA，并进行了系统的合成和抗病毒活性评价。生物测定结果表明，这些化合物大多数表现出良好到优异的体内抗 TMV 活性，其中化合物 19 和 27 的活性高于商业利巴韦林，因此成为潜在的植物病毒抑制剂。新颖的简洁结构为抗病毒研究提供了另一个新模板。
