Department of Neurology, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Chin Med J (Engl). 2012 Jul;125(13):2365-70.
This review discusses the experimental and clinical studies those show the expression of connexin 36 in the central nervous system and the possible role of connexin 36 in epileptic seizure.
All articles used in this review were mainly searched from PubMed published in English from 1996 to 2012.
Original articles and reviews were selected if they were related to the expression of connexin 36 in the central nervous system and its role in epilepsy.
The distribution of connexin 36 is developmentally regulated, cell-specific and region-specific. Connexin 36 is involved in some neuronal functions and epileptic synchronization. Changes in the connexin 36 gene and protein were accompanied by seizures. Selective gap junction blockers have exerted anticonvulsant actions in a variety of experiments examined in both humans and experimental animals.
Connexin 36 plays an important role in both physiological and pathological conditions in the central nervous system. A better understanding of the role of connexin 36 in seizure activity may contribute to the development of new therapeutic approaches to treating epilepsy.
本综述讨论了中枢神经系统中连接蛋白 36 的表达及其在癫痫发作中可能作用的实验和临床研究。
本综述中使用的所有文章均主要从 1996 年至 2012 年以英文发表在 PubMed 上的文章中搜索获得。
如果与中枢神经系统中连接蛋白 36 的表达及其在癫痫中的作用相关，则选择原始文章和综述。
连接蛋白 36 的分布具有发育调节、细胞特异性和区域特异性。连接蛋白 36 参与一些神经元功能和癫痫同步。连接蛋白 36 基因和蛋白的变化伴随着癫痫发作。在人类和实验动物的各种实验中，选择性缝隙连接阻滞剂已显示出抗惊厥作用。
连接蛋白 36 在中枢神经系统的生理和病理条件下均发挥重要作用。更好地了解连接蛋白 36 在癫痫发作活动中的作用可能有助于开发治疗癫痫的新治疗方法。
