Hunter E G, Frank G B
Can J Physiol Pharmacol. 1979 Oct;57(10):1171-4. doi: 10.1139/y79-173.
The effect of meperidine (3 X 10(4) M) on the action potential of frog sciatic nerve was examined by means of the double sucrose gap technique. Meperidine decreased the amplitude, maximum rate of depolarization, and maximum rate of repolarization of the action potential but had no effect on the resting potential. This depression in amplitude and maximum rate of rise was partially blocked by naloxone (1 X 10(-8) M) while the maximum rate of depolarization was further depressed. The data suggest that the effect of meperidine is due to two mechanisms, a nonspecific local anaesthetic like effect and an opiate receptor mediated effect.
采用双蔗糖间隙技术研究了哌替啶（3×10⁴M）对蛙坐骨神经动作电位的影响。哌替啶降低了动作电位的幅度、最大去极化速率和最大复极化速率，但对静息电位无影响。纳洛酮（1×10⁻⁸M）部分阻断了这种幅度和最大上升速率的降低，而最大去极化速率进一步降低。数据表明，哌替啶的作用是由两种机制引起的，一种是非特异性的局部麻醉样作用，另一种是阿片受体介导的作用。
