[25-羟维生素D水平与高血压关系的Meta分析]

[Meta-analysis on the relationship between 25-hydroxyvitamin D level and hypertension].

作者信息

Liu Yi-Ting, Cai Yun-Fei, Shi Jing-Pu

机构信息

Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2012 May 15;92(18):1268-71.

PMID:22883066

Abstract

OBJECTIVE

To explore the association between 25-hydroxyvitamin D level and hypertension so as to provide rationales for developing preventive strategies and understanding the etiology of hypertension.

METHODS

The articles on the association of 25-hydroxyvitamin D level and hypertension were retrieved by searching international and national databases from 2000 to 2011. The relationship between 25-hydroxyvitamin D level and hypertension was assessed by Meta-analysis with Stata11.0 software.

RESULTS

The results of Meta analysis showed that the pooled OR values of hypertension with 25-hydroxyvitamin D level deficiency and sufficiency was 1.37 (95%CI 1.23 - 1.53). Subgroup analysis revealed in 25-hydroxyvitamin D level, can be drawn between 25-hydroxyvitamin D level and the incidence of hypertension was statistically significant. The pooled OR values of hypertension with 25-hydroxyvitamin D level in 35 nmol/L and 35 - 68 nmol/L were 2.02 (95%CI 1.49 - 2.74) and 1.23 (95%CI 1.02 - 1.49) (P < 0.05).

CONCLUSIONS

The 25-hydroxyvitamin D level is associated with hypertension. With regards to the question of whether or not the 25-hydroxyvitamin D level deficiency serves as one of the potential risk factor for hypertension, prospective studies of larger sample sizes are warranted.

摘要

目的

探讨25-羟维生素D水平与高血压之间的关联，为制定预防策略及了解高血压病因提供依据。

方法

通过检索2000年至2011年国际和国内数据库，获取关于25-羟维生素D水平与高血压关联的文章。使用Stata11.0软件通过Meta分析评估25-羟维生素D水平与高血压之间的关系。

结果

Meta分析结果显示，25-羟维生素D水平缺乏和充足时高血压的合并OR值为1.37（95%CI 1.23 - 1.53）。亚组分析显示，在25-羟维生素D水平方面，可得出25-羟维生素D水平与高血压发病率之间具有统计学意义。25-羟维生素D水平为35 nmol/L和35 - 68 nmol/L时高血压的合并OR值分别为2.02（95%CI 1.49 - 2.74）和1.23（95%CI 1.02 - 1.49）（P < 0.05）。