Peng Meng, Chen Shuohua, Jiang Xiongjing, Zhang Weiguo, Wang Yanxiu, Wu Shouling, Cardiovascular Survey Group On Behalf Of The Kailuan
Hypertension Center, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Intern Med. 2016;55(10):1255-60. doi: 10.2169/internalmedicine.55.5898. Epub 2016 May 15.
Objective The aim of this study was to evaluate the vitamin D status and the relationship between the vitamin D status and hypertension in a relatively large cohort in northern China. Methods This study was a part of the Kailuan study, consisting of 3,788 coal mine workers (including 2,532 underground workers and 1,256 surface workers) who received periodic health examinations between September 13, 2012 and December 24, 2012. Information on demographic factors, personal history and medical history were collected. The height, weight, blood pressure and serum25-hydroxyvitamin D [25(OH)D] level of each patient were measured. Results The mean 25(OH)D level in this cohort was 21.73±15.82 nmol/L. The number (%) of patients with vitamin D deficiency, insufficiency, inadequacy and sufficiency were 2,509 (66.24%), 1,051 (27.75%), 201 (5.31%) and 27 (0.71%), respectively. In all the participants, after adjusting for the age, salt intake, physical activity, smoking status, alcohol drinking status, work type, work environment, body mass index, diabetes and hyperlipidemia, the odds ratios for hypertension with 25(OH)D level ≥50, 25-50 and <25 nmol/L were 1.00 (reference), 1.44 (95%CI, 0.99-2.11) and 1.39 (95%CI, 0.97-1.99), respectively. Logistic regression models to evaluate the odds ratios and 95% CIs of hypertension for each quintile of the 25(OH)D level did not determine significant associations between the vitamin D status and hypertension. No significant associations were found in the underground workers or in the surface workers. Conclusion There was a high proportion of coal mine workers with vitamin D deficiency and insufficiency in Kailuan. However, no significant association between low vitamin D levels and hypertension was found in this cohort. Further investigations are needed to determine the relationship between vitamin D levels and hypertension.
目的 本研究旨在评估中国北方一个相对较大队列中的维生素D状况以及维生素D状况与高血压之间的关系。方法 本研究是开滦研究的一部分，纳入了2012年9月13日至2012年12月24日期间接受定期健康检查的3788名煤矿工人（包括2532名井下工人和1256名地面工人）。收集了人口统计学因素、个人史和病史等信息。测量了每位患者的身高、体重、血压和血清25-羟维生素D[25(OH)D]水平。结果 该队列中25(OH)D的平均水平为21.73±15.82 nmol/L。维生素D缺乏、不足、不充足和充足的患者人数（%）分别为2509（66.24%）、1051（27.75%）、201（5.31%）和27（0.71%）。在所有参与者中，在调整年龄、盐摄入量、身体活动、吸烟状况、饮酒状况、工作类型、工作环境、体重指数、糖尿病和高脂血症后，25(OH)D水平≥50、25 - 50和<25 nmol/L时高血压的比值比分别为1.00（参照）、1.44（95%CI，0.99 - 2.11）和1.39（95%CI，0.97 - 1.99）。用于评估25(OH)D水平每个五分位数高血压的比值比和95%CI的逻辑回归模型未确定维生素D状况与高血压之间存在显著关联。在井下工人或地面工人中也未发现显著关联。结论 开滦煤矿工人中维生素D缺乏和不足的比例较高。然而，在该队列中未发现低维生素D水平与高血压之间存在显著关联。需要进一步研究以确定维生素D水平与高血压之间的关系。
