Wang Juan, Zhang Fang-fang, Yu Xu-en, Han Yong-sheng, Han Yong-zhu, Wang Kai
Department of Neurology, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
Zhonghua Yi Xue Za Zhi. 2012 May 22;92(19):1304-6.
To explore the presence of impaired decision-making functions of Wilson's disease patients in Iowa gambling task (IGT) and its association with basal ganglia damage.
Thirty-two IGT patients with WD (WD group) and 29 healthy people (control group) were recruited from the same period. And two options of high and low rewards were selected. Before the start of experiment, a basal figure of 2000 yuan was shown on computer display and they were prompted to win more money as much as possible. The general trend was observed with or without social learning effects.
With the increased number of cards selected, the number of favorable and unfavorable selections shifted from negative to positive and gradually rose in the control group. However, such a pattern was absent in the WD group. The WD patients in the IGT group in Trial4 and Trial5 were significantly lower than the controls (P = 0.009 and P = 0.020).
The WD IGT patients have significant impairments of policy-making functions due to the damage of basal ganglia. And the effects of copper metabolism on cerebral cortex should be further studied in WD patients.
探讨肝豆状核变性（WD）患者在爱荷华赌博任务（IGT）中决策功能受损情况及其与基底节损害的关系。
同期招募32例WD患者（WD组）和29例健康人（对照组）。选择高奖励和低奖励两种选项。实验开始前，电脑显示屏上显示2000元的初始金额，并提示他们尽可能赢取更多的钱。观察有无社会学习效应时的总体趋势。
随着所选纸牌数量的增加，对照组中有利和不利选择的数量从负向正转变并逐渐上升。然而，WD组未出现这种模式。IGT组中WD患者在第4次和第5次试验中的得分显著低于对照组（P = 0.009和P = 0.020）。
WD-IGT患者因基底节损害而存在显著的决策功能障碍。WD患者铜代谢对大脑皮层的影响有待进一步研究。
