Lin Yao, Gu Shu-jun, Wu Ming, Chen Qiu, Zhou Zheng-yuan, Yu Hao, Zhang Li-jun, Luo Wen-shu, Guo Zhi-rong
Department of Public Health, Soochow University, Suzhou 215123, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Jun;33(6):597-601.
To investigate the association between ten single nucleotide polymorphism (SNP) in the peroxisome proliferator-activated receptor (PPAR) α/δ/γ and essential hypertension (EH).
Participants were recruited within the framework of a cohort populations survey from the PMMJS (Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province) which was conducted in the urban community of Jiangsu province from 1999 to 2007. Eight hundred and twenty subjects (551 non-hypertensive subjects, 269 hypertensive subjects) were randomly selected but were not related to each other. Ten SNP (rs135539, rs1800206, rs4253778 of PPARα; rs2016520, rs9794 of PPARδ; rs10865710, rs1805192, rs4684847, rs709158 and rs3856806 of PPARγ) were selected from the HapMap database. χ(2) test was used to determine whether the whole population was in H-W genetic equilibrium. SHEsis software was used to examine the relations of SNP and linkage equilibrium. Logistic regression model was used to examine the association between ten SNP in the PPAR and EH.
Difference on the distribution of four SNP genotypes including rs1800206, rs9794, rs10865710 and rs4684847 between high blood pressure and non-high blood pressure group, high systolic blood pressure (SBP) and normal SBP group, high diastolic blood pressure (DBP) and normal DBP group was significant (P < 0.05). After adjusting factors as age, sex, body mass index, fasting plasma glucose, high density lipoprotein cholesterol-C, high-fat diet and compared with wild-type gene carriers, the OR (95%CI) of objects with rs1800206 V allele appeared in high blood pressure, high SBP and high DBP were 0.60 (0.41 - 0.89), 0.57 (0.37 - 0.88) and 0.61 (0.39 - 0.96), respectively. The OR (95%CI) of objects with G allele of rs9794 were 0.63 (0.46 - 0.87), 0.51 (0.36 - 0.73) and 0.68 (0.47 - 1.01). The OR (95%CI) of objects with G allele of rs10865710 were 1.62 (1.19 - 2.20), 1.59 (1.14 - 2.22) and 1.53 (1.07 - 2.18), respectively. While the OR (95%CI) of objects with rs4684847 T allele were 1.42 (1.04 - 1.94), 1.38 (1.03 - 1.92) and 1.37 (1.00 - 1.88), respectively.
The four SNPs including rs1800206 of PPARα, rs9794 of PPARδ and rs4684847, rs10865710 of PPARγ influenced high blood pressure, high SBP and high DBP to different degrees.
探讨过氧化物酶体增殖物激活受体（PPAR）α/δ/γ基因的10个单核苷酸多态性（SNP）与原发性高血压（EH）之间的关联。
在江苏省城市社区进行的一项队列人群调查（江苏省多种代谢紊乱和MS的预防，PMMJS）框架内招募参与者，该调查于1999年至2007年进行。随机选择820名受试者（551名非高血压受试者，269名高血压受试者），且他们彼此无关。从HapMap数据库中选择10个SNP（PPARα的rs135539、rs1800206、rs4253778；PPARδ的rs2016520、rs9794；PPARγ的rs10865710、rs1805192、rs4684847、rs709158和rs3856806）。采用χ(2)检验确定总体是否处于哈迪-温伯格（H-W）遗传平衡。使用SHEsis软件检查SNP之间的关系和连锁平衡。采用逻辑回归模型检验PPAR基因中的10个SNP与EH之间的关联。
高血压组与非高血压组、高收缩压（SBP）组与正常SBP组、高舒张压（DBP）组与正常DBP组之间，rs18…
