Gu Shu-Jun, Chen Dong-Hui, Guo Zhi-Rong, Zhou Zheng-Yuan, Hu Xiao-Shu, Wu Ming
Center for Disease Control of Changshu, Suzhou, 215500, Jiangsu, China.
Endocrine. 2015 Feb;48(1):195-202. doi: 10.1007/s12020-014-0218-x. Epub 2014 Mar 7.
The peroxisome proliferator-activated receptors (PPARs)-α, -β/δ, and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, inflammation, and atherosclerosis. Our aim was to test the association between ten single nucleotide polymorphisms of PPARs and CRP level, as well as their interaction with overweight/obesity. A sample population of 643 subjects was recruited from the prevention of MetS and multi-metabolic disorders in Jiangsu Province of China Study. The selected SNPs in PPAR α (rs135539, rs4253778, rs1800206), PPAR β/δ (rs2016520 and rs9794), and PPAR γ (rs10865710, rs1805192, rs709158, rs3856806, and rs4684847) were genotyped. After adjustment for smoking, alcohol consumption, SBP, DBP, TG, and HDL-C, rs1800206, rs709158, rs1805192, and rs4684847 polymorphisms were significantly associated with CRP level in normal weight subjects (P < 0.05). In the overweight/obese subjects, rs1800206 was also significant associated with CRP level (P<0.01). In addition, the rs709158, rs1805192, and rs4684847 polymorphisms were shown interactions with overweight/obesity to influence CRP level (P<0.05). PPARs polymorphisms are independently associated with CRP levels in Chinese Han population. Further, PPARs polymorphisms interact with overweight/obesity to set CRP levels.
过氧化物酶体增殖物激活受体（PPARs）-α、-β/δ和-γ是配体激活的转录因子，作为葡萄糖、脂肪酸和脂蛋白代谢、炎症及动脉粥样硬化的主要调节因子发挥作用。我们的目的是检测PPARs的十个单核苷酸多态性与CRP水平之间的关联，以及它们与超重/肥胖的相互作用。从中国江苏省预防代谢综合征和多种代谢紊乱研究中招募了643名受试者作为样本群体。对PPARα（rs135539、rs4253778、rs1800206）、PPARβ/δ（rs2016520和rs9794）和PPARγ（rs10865710、rs1805192、rs709158、rs3856806和rs4684847）中选定的单核苷酸多态性进行基因分型。在对吸烟、饮酒、收缩压、舒张压、甘油三酯和高密度脂蛋白胆固醇进行校正后，rs1800206、rs709158、rs1805192和rs4684847多态性与正常体重受试者的CRP水平显著相关（P<0.05）。在超重/肥胖受试者中，rs1800206也与CRP水平显著相关（P<0.01）。此外，rs709158、rs1805192和rs4684847多态性显示出与超重/肥胖相互作用以影响CRP水平（P<0.05）。PPARs多态性在中国汉族人群中与CRP水平独立相关。此外，PPARs多态性与超重/肥胖相互作用以设定CRP水平。
