检测儿童过敏性紫癜伴中枢神经系统受累的抗磷脂抗体。

Detection of antiphospholipid antibody in children with Henoch-Schönlein purpura and central nervous system involvement.

机构信息

Department of Pediatrics, Peking University First Hospital, Beijing, China; Department of Pediatrics, First People's Hospital of Yunnan Province, Kunming, China.

出版信息

Pediatr Neurol. 2012 Sep;47(3):167-70. doi: 10.1016/j.pediatrneurol.2012.05.024.

DOI:10.1016/j.pediatrneurol.2012.05.024

PMID:22883280

Abstract

To explore the mechanisms of central nervous system involvement in children with Henoch-Schönlein purpura, levels of lupus anticoagulant, anticardiolipin antibodies, and anti-β2 glycoprotein I antibodies in serum and cerebrospinal fluid were determined in 46 cases of Henoch-Schönlein purpura with central nervous system involvement. Results indicated that Henoch-Schönlein purpura with central nervous system involvement produced a higher total percentage of antiphospholipid antibodies in serum and cerebrospinal fluid, compared with viral encephalitis control subjects (76.1% vs 10.0% and 71.7% vs 0.0%, respectively; P < 0.05). Henoch-Schönlein purpura may be associated with antiphospholipid syndrome or antiphospholipid antibodies, which may account for the neurologic damage in Henoch-Schönlein purpura.

摘要

为了探究中枢神经系统受累的过敏性紫癜患儿的发病机制，检测了 46 例中枢神经系统受累的过敏性紫癜患儿血清和脑脊液中狼疮抗凝物、抗心磷脂抗体和抗β2 糖蛋白 I 抗体的水平。结果表明，与病毒性脑炎对照组相比，中枢神经系统受累的过敏性紫癜患儿血清和脑脊液中的抗磷脂抗体总阳性率更高（分别为 76.1%比 10.0%和 71.7%比 0.0%；P<0.05）。过敏性紫癜可能与抗磷脂综合征或抗磷脂抗体有关，这可能是过敏性紫癜患儿神经损伤的原因。