Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Pediatr Neurol. 2012 Sep;47(3):213-5. doi: 10.1016/j.pediatrneurol.2012.04.024.
Miller Fisher syndrome is a clinical variant of Guillain-Barré syndrome, characterized by acute-onset ophthalmoplegia, ataxia, and areflexia. It results from an immune response to a cross-reactive antigen between GQ1b ganglioside in human neurons and lipo-oligosaccharides of certain bacteria, e.g., Campylobacter jejuni. Anti-GQ1b antibody is a powerful diagnostic marker for Miller Fisher syndrome. However, only a small number of anti-GQ1b-negative Miller Fisher syndrome cases are documented. A 13-year-old boy demonstrated typical clinical features of Miller Fisher syndrome 1 week after C. jejuni enteritis, but was anti-GQ1b and anti-GM1b antibody-negative.
米勒费雪综合征是吉兰-巴雷综合征的一种临床变异型，以急性眼肌麻痹、共济失调和反射消失为特征。它是由针对人类神经元 GQ1b 神经节苷脂和某些细菌（如空肠弯曲菌）脂寡糖的交叉反应抗原的免疫反应引起的。抗 GQ1b 抗体是米勒费雪综合征的强有力的诊断标志物。然而，仅有少数抗 GQ1b 阴性的米勒费雪综合征病例有记录。一名 13 岁男孩在空肠弯曲菌肠炎后 1 周出现典型的米勒费雪综合征临床特征，但抗 GQ1b 和抗 GM1b 抗体均为阴性。
