Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Mol Cell. 2012 Aug 10;47(3):333-4. doi: 10.1016/j.molcel.2012.07.024.
Studies from Ciccia et al. (2012) and Yuan et al. (2012) in this issue of Molecular Cell, together with Weston et al. (2012), reveal that the translocase ZRANB3/AH2 can recognize K63-linked polyubiquitinated PCNA and plays an important role in restarting stalled replication forks.
西奇亚等人(2012 年)和袁等人(2012 年)在本期《分子细胞》上的研究,以及韦斯顿等人(2012 年)的研究表明,RANB3/AH2 转位酶可以识别 K63 连接的多聚泛素化 PCNA,并在重新启动停滞的复制叉中发挥重要作用。