Holmes Christina M, Goldman Mitchell J
Department of Pediatrics, Peyton Manning Children's Hospital, Indianapolis, Indiana 46240, USA.
J Emerg Med. 2012 Dec;43(6):e447-9. doi: 10.1016/j.jemermed.2012.02.068. Epub 2012 Aug 9.
Gelastic seizures are defined as seizure activity manifesting as laughter inappropriate to the situation, with supporting evidence on electroencephalogram or magnetic resonance imaging. Gelastic seizures are most commonly reported in patients with hypothalamic hamartomas causing precocious puberty. The differential diagnosis of incessant laughter is important to recognize in the Emergency Department, as some conditions warrant immediate treatment and others require further diagnostic work-up with implications for the entire family.
The background and pathophysiology of gelastic epilepsy will be discussed.
The case of a previously healthy girl with acute onset of incessant laughter is reported. This patient was diagnosed with a clinical case of gelastic seizures. This case illustrates the importance of recognizing this form of seizures for accurate treatment and follow-up.
This case report illustrates the importance of a broad differential for a patient presenting emergently with uncontrollable laughter. Gelastic epilepsy is relatively rare but requires further work-up and often may require chronic therapy.
痴笑性癫痫发作被定义为发作活动表现为与情境不符的笑声，脑电图或磁共振成像有支持证据。痴笑性癫痫发作最常见于患有下丘脑错构瘤并导致性早熟的患者。在急诊科，对持续性笑声进行鉴别诊断很重要，因为有些情况需要立即治疗，而另一些情况则需要进一步的诊断检查，这对整个家庭都有影响。
将讨论痴笑性癫痫的背景和病理生理学。
报告了一名既往健康的女孩急性起病出现持续性笑声的病例。该患者被诊断为痴笑性癫痫的临床病例。该病例说明了识别这种癫痫发作形式对于准确治疗和随访的重要性。
本病例报告说明了对突然出现无法控制的笑声的患者进行广泛鉴别诊断的重要性。痴笑性癫痫相对罕见，但需要进一步检查，且通常可能需要长期治疗。
