Mazzocchi G, Belloni A S, Rebuffat P, Robba C, Neri G, Nussdorfer G G
Cell Tissue Res. 1979 Sep 3;201(2):165-79. doi: 10.1007/BF00235055.
The fine structure of the rabbit adrenal cortex was investigated. The parenchymal cells display the ultrastructural features of steroid-producing cells, and also contain numerous electron-dense bodies frequently located near intercellular canaliculi, when open into the subendothelial space. Short-term ACTH-administration induced a noticeable decrease in the volume of the lipid compartment in the cells of all three cortical zones and a significant increase in the volume of dense bodies in the cells of zona fasciculata and zona reticularis. The hypothesis that these dense bodies are secretory granules is discussed in the light of biochemical evidence showing that ACTH increases the concentration of both corticosterone and cortisol in the decapsulated-enucleated adrenal homogenate and does not affect the activity of two lysosome-marker enzymes (i.e., acid phosphatase and beta-glucuronidase).
对兔肾上腺皮质的精细结构进行了研究。实质细胞呈现出类固醇生成细胞的超微结构特征，并且还含有大量电子致密体，这些致密体通常位于通向内皮下间隙的细胞间小管附近。短期给予促肾上腺皮质激素（ACTH）会导致所有三个皮质带细胞中的脂质区室体积显著减小，而束状带和网状带细胞中的致密体体积则显著增加。鉴于生化证据表明ACTH可增加去包膜去核肾上腺匀浆中皮质酮和皮质醇的浓度，且不影响两种溶酶体标记酶（即酸性磷酸酶和β-葡萄糖醛酸酶）的活性，因此对这些致密体是分泌颗粒这一假说进行了讨论。
