Guidelines for the use of zidovudine for post-exposure prophylaxis after needlestick injuries in health care settings.

A protocol for the management of health care personnel after exposure to the human immunodeficiency virus in the workplace is set out. The use of zidovudine is advocated, although sufficient evidence for its use in these circumstances is lacking. Recommendations for zidovudine chemoprophylaxis, including dosage regimens, duration of therapy, and laboratory monitoring tests, are given. The need to avoid occupational needlestick injuries is stressed.