Department of Pediatric, Harran University Medical Faculty, 63100 Sanliurfa, Turkey.
Clin Neuroradiol. 2013 Mar;23(1):25-30. doi: 10.1007/s00062-012-0163-0. Epub 2012 Aug 12.
This study aimed to evaluate the contribution of diffusion weighted magnetic resonance imaging to the diagnosis and staging of subacute sclerosing panencephalitis.
The study comprised 26 patients diagnosed with subacute sclerosing panencephalitis at our clinic who were undergoing regular follow-up, and a control group of 18 subjects. Clinical staging was determined by Risk and Haddad classification; 12 at Stage II and 14 at Stage III. Diffusion weighted magnetic resonance images were taken of six areas (frontal, parieto-occipital, cerebellar, deep white matter, thalamus and basal ganglia) and by calculating the apparent diffusion coefficient (ADC) values, and a comparison was made between the stages and with the control group.
The ADC values of all the areas of the subacute sclerosing panencephalitis patients were found to be significantly higher compared to the control group (p < 0.05). While the mean ADC values of the deep white matter, basal ganglia, frontal and parieto-occipital areas of the Stage II patients were found to be significant compared to the control group (p < 0.05), there was no significance in the other areas (p > 0.05). The ADC values of all the areas of the Stage III patients were found to be significantly high compared to the Stage II values (p < 0.05).
Diffusion weighted magnetic resonance imaging can be used with other diagnostic criteria to confirm diagnosis of subacute sclerosing panencephalitis and to reveal differences between the stages.
本研究旨在评估磁共振弥散加权成像对亚急性硬化性全脑炎的诊断和分期的贡献。
本研究纳入了 26 例在我院接受常规随访的亚急性硬化性全脑炎患者，并纳入了 18 名对照组受试者。临床分期采用 Risk 和 Haddad 分类法确定；12 例为 II 期，14 例为 III 期。对 6 个部位（额、顶枕、小脑、深部白质、丘脑和基底节）进行磁共振弥散加权成像，并计算表观弥散系数（ADC）值，比较各期之间和与对照组之间的差异。
所有亚急性硬化性全脑炎患者的 ADC 值均明显高于对照组（p<0.05）。II 期患者深部白质、基底节、额部和顶枕部的平均 ADC 值与对照组相比差异有统计学意义（p<0.05），而其他部位无显著性差异（p>0.05）。III 期患者所有部位的 ADC 值均明显高于 II 期（p<0.05）。
磁共振弥散加权成像可与其他诊断标准一起用于确诊亚急性硬化性全脑炎，并揭示各期之间的差异。
