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透析在腹膜透析中的疗效:生物阻抗在计算 Kt/V 中的应用和目标 Kt 的寻找。

Efficacy of dialysis in peritoneal dialysis: utility of bioimpedance to calculate Kt/V and the search for a target Kt.

机构信息

Nephrology Unit, University Hospital of Albacete, C/Hnos Falcó 37, 02006, Albacete, Spain.

出版信息

Clin Exp Nephrol. 2013 Apr;17(2):261-7. doi: 10.1007/s10157-012-0671-x. Epub 2012 Aug 11.

DOI:10.1007/s10157-012-0671-x
PMID:22886499
Abstract

BACKGROUND

To calculate Kt/V, volume (V) is usually obtained by Watson formula, but bioimpedance spectroscopy (BIS) is a simple and applicable technique to determinate V, along with other hydration and nutrition parameters, in peritoneal dialysis (PD) patients. Dialysis efficacy can also be measured with Kt, but no experience exists in PD, so there is no reference/target value for Kt that must be achieved in these patients to be considered adequately dialyzed. We evaluated the efficacy of PD with Kt/V using Watson formula and BIS for V calculation, assessed hydration status in a PD unit by data obtained by BIS, and attempted to find a reference Kt from the Kt/V previously obtained by BIS.

METHODS

In this observational prospective study of 78 PD patients, we measured V using BIS (V bis) and Watson formula (V w) and calculated weekly Kt/V using both volumes (Kt/V bis/V bis and Kt/V w). With the BIS technique, we obtained and subsequently analyzed other hydration status parameters. We achieved a reference Kt, extrapolating the value desired (weekly Kt/V 1.7) to the target Kt using the simple linear regression statistical technique, basing it on the results of the previously calculated Pearson's linear correlation coefficient.

RESULTS

Volume was 1.8 l higher by Watson formula than with BIS (p < 0.001). Weekly Kt/V bis was 2.33 ± 0.68, and mean weekly Kt/V w was 2.20 ± 0.63 (p < 0.0001); 60.25 % of patients presented overhydration according to the BIS study (OH >1.1 l). The target value of Kt for the reference weekly Kt/V bis (1.7) was 64.87 l.

CONCLUSIONS

BIS is a simple, applicable technique for calculating V in dialysis that can be especially useful in PD patients compared with the anthropometric formulas, by the abnormally distributed body water in these patients. Other parameters obtained by BIS will serve to assess both the distribution of body volume and nutritional status in the clinical setting. The target Kt value obtained from Kt/V bis allowed us to measure the efficacy of PD in a practical way, omitting V measurement.

摘要

背景

为了计算 Kt/V,通常通过 Watson 公式获得体积(V),但生物电阻抗谱(BIS)是一种简单且适用的技术,可在腹膜透析(PD)患者中确定 V 以及其他水合和营养参数。透析效果也可以用 Kt 来衡量,但在 PD 中没有经验,因此没有参考/目标值,这些患者必须达到该值才能被认为透析充分。我们使用 Watson 公式和 BIS 计算 V 来评估 PD 的效果,通过 BIS 获得的数据评估 PD 单位的水合状态,并尝试从之前通过 BIS 获得的 Kt/V 中找到参考 Kt。

方法

在这项对 78 名 PD 患者的观察性前瞻性研究中,我们使用 BIS(Vbis)和 Watson 公式(Vw)测量 V,并使用两种体积计算每周 Kt/V(Kt/Vbis/Vbis 和 Kt/Vw)。使用 BIS 技术,我们获得并随后分析了其他水合状态参数。我们通过简单线性回归统计技术,从之前计算的 Pearson 线性相关系数中,外推所需值(每周 Kt/V 1.7),获得参考 Kt。

结果

Watson 公式比 BIS 多算出 1.8 升(p < 0.001)。每周 Kt/Vbis 为 2.33 ± 0.68,平均每周 Kt/Vw 为 2.20 ± 0.63(p < 0.0001);根据 BIS 研究,60.25%的患者存在水过多(OH >1.1 升)。参考每周 Kt/Vbis(1.7)的目标 Kt 值为 64.87 升。

结论

BIS 是一种计算透析患者 V 的简单、适用技术,与这些患者异常分布的人体水分相比,该技术尤其适用于 PD 患者。BIS 获得的其他参数将有助于评估临床环境中体容积和营养状况的分布。从 Kt/Vbis 获得的目标 Kt 值使我们能够以一种实用的方式测量 PD 的效果,而无需测量 V。

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PLoS One. 2011 Feb 24;6(2):e17148. doi: 10.1371/journal.pone.0017148.
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Relations between malnutrition-inflammation-atherosclerosis and volume status. The usefulness of bioimpedance analysis in peritoneal dialysis patients.营养不良-炎症-动脉粥样硬化与容量状态的关系。生物电阻抗分析在腹膜透析患者中的应用。
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Normalized bioimpedance indices are better predictors of outcome in peritoneal dialysis patients.
归一化生物阻抗指数是腹膜透析患者预后的更好预测指标。
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