环孢素对脂肪酸支持的线粒体呼吸的抑制作用。
Inhibition of fatty acid-supported mitochondrial respiration by cyclosporine.
作者信息
Lemmi C A, Miller R L, Rajfer J
机构信息
Department of Anatomy and Cell Biology, UCLA 90024.
出版信息
Biochem Med Metab Biol. 1990 Dec;44(3):266-70. doi: 10.1016/0885-4505(90)90071-8.
PMID:2288768
Abstract
We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity.
摘要
我们已经表明，除了抑制琥珀酸支持的能量途径（5）外，CS对线粒体复合物II活性的抑制也限制了脂肪酸氧化。这些结果与脂质代谢改变参与CS肾毒性一致。
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