C-H 键功能化：天然产物和药物合成的新兴工具。
C-H bond functionalization: emerging synthetic tools for natural products and pharmaceuticals.
机构信息
Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):8960-9009. doi: 10.1002/anie.201201666. Epub 2012 Aug 6.
PMID:22887739
Abstract
The direct functionalization of C-H bonds in organic compounds has recently emerged as a powerful and ideal method for the formation of carbon-carbon and carbon-heteroatom bonds. This Review provides an overview of C-H bond functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets.
摘要
在有机化合物中，C-H 键的直接官能化最近已成为形成碳-碳和碳-杂原子键的一种强大而理想的方法。本文综述了 C-H 键官能化策略在快速合成生物活性化合物（如天然产物和药物靶点）方面的应用。
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