Majola Nonhlelo, Jeena Vineet
School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, Pietermaritzburg 3209, South Africa.
Molecules. 2024 Dec 22;29(24):6047. doi: 10.3390/molecules29246047.
Benzylic C-H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates. In this review, we highlight the synthesis of aromatic ketones via catalytic, electrochemical, and photochemical oxidation of alkylarenes using different catalysts and oxidants in the past 5 years. Additionally, we also discuss the synthesis of heterocyclic molecules using benzylic C-H oxidation as a key step. These methods can potentially be used in medicinal, synthetic, and inorganic chemistry.
苄基C-H氧化形成羰基化合物（如酮）是有机合成中的一种基本转化反应，因为它能制备多种中间体。在本综述中，我们重点介绍了过去5年中通过使用不同催化剂和氧化剂对烷基芳烃进行催化、电化学和光化学氧化来合成芳香酮的方法。此外，我们还讨论了以苄基C-H氧化为关键步骤来合成杂环分子的方法。这些方法有可能应用于药物化学、合成化学和无机化学领域。
