Max Planck Institute of Colloids and Interfaces, Department of Colloid Chemistry, Potsdam, Germany.
Macromol Biosci. 2012 Sep;12(9):1272-8. doi: 10.1002/mabi.201200131. Epub 2012 Aug 6.
Bioconjugate amphiphiles comprising triterpene and poly(ethylene oxide) (PEO) were studied according to their thermoresponsive aggregation behavior (LCST) in water. Cholesteryl-PEO (CE) and betulinyl-PEO (BE) comprising <70 wt% PEO precipitated from water upon heating. CE, but not BE, solutions contained nanoscopic aggregates at room temperature causing different thermoprecipitation behaviors. Solutions containing 5 wt% solutions of BE with short PEO chains demonstrated dual thermoresponsive behavior, precipitating at high temperature and forming hydrogel at low temperature. A BE multiblock copolymer was found to form large aggregates, presumably vesicles, in water. Results suggest that the solution properties of triterpene-PEO amphiphiles can be controlled by the chemical composition and structure.
研究了包含三萜和聚环氧乙烷（PEO）的生物共轭两亲物，根据其在水中的温敏聚集行为（LCST）。胆固醇-PEO（CE）和桦木醇-PEO（BE）包含 <70wt% 的 PEO，在加热时从水中沉淀出来。CE 但不是 BE 溶液在室温下含有纳米级聚集体，导致不同的热沉淀行为。含有 5wt%短 PEO 链 BE 的溶液表现出双重温敏行为，在高温下沉淀并在低温下形成水凝胶。发现 BE 多嵌段共聚物在水中形成大的聚集体，可能是囊泡。结果表明，三萜-PEO 两亲物的溶液性质可以通过化学组成和结构来控制。
