Chetverikov S H, Iashchenko A M, Ier'omin Iu V, Vododiuk V Iu
Klin Khir. 2012 May(5):19-23.
The results of treatment of 122 patients, to whom alloplasty for postoperative abdominal hernia (POAH) was performed, were analyzed. In 76 patients a connective tissue dysplasia (CTD) was diagnosed.Determination of a various types of collagen content in connective tissue of patients, suffering CTD, may confirm or exclude this diagnosis. Diagnostic significance has the enhancement of a collagen type III content in comparison with such of a type I by three times and more. The method of lectinohistochemical investigation of connective tissue was applied as a precision-enhancing method of a CTD diagnosis. Mosaic or diffuse loss of SNA, LABA, ConA receptors of lectins by collagen fascicles, which reflect carbohydrate determinants of dense and strong collagen fascicles, made of collagen type I, witness the CTD presence. Along with this, there was observed a lectin WGA receptors expression increase, which constitutes a marker of fascicular structures, made of collagen, predominantly type III and a lectin PNA receptors, which are revealed around vessels.
对122例行术后腹疝（POAH）同种异体成形术的患者的治疗结果进行了分析。76例患者被诊断为结缔组织发育异常（CTD）。测定CTD患者结缔组织中各种类型胶原蛋白的含量，可证实或排除该诊断。与I型胶原蛋白相比，III型胶原蛋白含量增加三倍及以上具有诊断意义。采用凝集素组织化学研究结缔组织的方法作为提高CTD诊断准确性的方法。胶原蛋白束对凝集素SNA、LABA、ConA受体的镶嵌或弥漫性缺失，反映了由I型胶原蛋白构成的致密且坚固的胶原蛋白束的碳水化合物决定簇，证明了CTD的存在。与此同时，还观察到凝集素WGA受体表达增加，这是由主要为III型胶原蛋白构成的束状结构的标志物，以及在血管周围发现的凝集素PNA受体。
