Carlsson A
Psychol Med. 1977 Nov;7(4):583-97. doi: 10.1017/s003329170000622x.
Inhibition of central dopamine functions appears to be a common basic property of antipsychotic drugs. The mesolimbic and nigrostriatal portions of the dopaminergic system are probably the main targets of these drugs for the mental and the extrapyramidal actions respectively. Dopaminergic hyperfunction, induced by amphetamines or dopa, may lead to a disturbance mimicking paranoid schizophrenia, lending further support for a key role of dopamine in mental functions. While a primary disturbance in dopamine function in schizophrenia cannot be ruled out, the intimate relationship between dopaminergic and other neuronal systems must be emphasized. The possible involvement of other amine, aminoacid or peptide transmitters in schizophrenia cannot be disregarded.
抑制中枢多巴胺功能似乎是抗精神病药物的一个共同基本特性。多巴胺能系统的中脑边缘和黑质纹状体部分可能分别是这些药物产生精神作用和锥体外系作用的主要靶点。由苯丙胺或多巴诱发的多巴胺能功能亢进可能导致类似偏执型精神分裂症的紊乱，这进一步支持了多巴胺在精神功能中起关键作用的观点。虽然不能排除精神分裂症中多巴胺功能的原发性紊乱，但必须强调多巴胺能系统与其他神经元系统之间的密切关系。不能忽视其他胺类、氨基酸或肽类递质可能参与精神分裂症的情况。
