Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Adv Neurobiol. 2024;40:285-319. doi: 10.1007/978-3-031-69491-2_11.
Event-related potentials (ERPs) are small voltage changes in the brain that reliably occur in response to auditory or visual stimuli. ERPs have been extensively studied in both humans and animals to identify biomarkers, test pharmacological agents, and generate testable hypotheses about the physiological and genetic basis of schizophrenia. In this chapter, we discuss how ERPs are generated and recorded as well as review canonical ERP components in the context of schizophrenia research in humans. We then discuss what is known about rodent homologs of these components and how they are altered in common pharmacologic and genetic manipulations used in preclinical schizophrenia research. This chapter will also explore the relationship of ERPs to leading hypotheses about the pathophysiology of schizophrenia. We conclude with an evaluation of both the utility and limitations of ERPs in schizophrenia research and offer recommendations of future directions that may be beneficial to the field.
事件相关电位（ERPs）是大脑中与听觉或视觉刺激相关的小电压变化，在人类和动物中都被广泛研究，以确定生物标志物、测试药物，并对精神分裂症的生理和遗传基础提出可检验的假设。在本章中，我们讨论了 ERPs 的产生和记录方式，并回顾了人类精神分裂症研究中经典的 ERP 成分。然后，我们讨论了这些成分在啮齿动物中的同源物是什么，以及它们在精神分裂症的临床前研究中常用的药理学和遗传学操作中是如何改变的。本章还将探讨 ERPs 与精神分裂症病理生理学的主要假说之间的关系。最后，我们对 ERPs 在精神分裂症研究中的效用和局限性进行了评估，并为该领域可能有益的未来方向提出了建议。
