Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia.
Dalton Trans. 2012 Oct 28;41(40):12329-45. doi: 10.1039/c2dt31045g.
A brief overview of mechanistic studies on the reactions of different Pt(II) complexes with nitrogen- and sulfur-donor biomolecules is presented. The first part describes the results obtained for substitution reactions of mono-functional Pt(II) complexes with different biomolecules, under various experimental conditions (temperature, pH and ionic strength). In addition, an overview of the results obtained for the substitution reactions of bi-functional Pt(II) complexes, analogous to cisplatin, with biomolecules is given. The last part of this report deals with different polynuclear Pt(II) complexes and their substitution behaviour with different biomolecules. The purpose of this perspective is to improve the understanding of the mechanism of action of Pt(II) complexes as potential anti-tumour drugs in the human body.
本文简要概述了不同 Pt(II) 配合物与氮、硫供体生物分子反应的机理研究。第一部分描述了在不同实验条件（温度、pH 值和离子强度）下，单官能 Pt(II) 配合物与不同生物分子的取代反应的结果。此外，还概述了类似顺铂的双官能 Pt(II) 配合物与生物分子的取代反应的结果。本报告的最后一部分涉及不同的多核 Pt(II) 配合物及其与不同生物分子的取代行为。本综述的目的是提高对 Pt(II) 配合物作为潜在抗肿瘤药物在人体内作用机制的理解。
