Kolonin Mikhail G
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Methods Mol Biol. 2012;904:243-52. doi: 10.1007/978-1-61779-943-3_20.
The course of various pathological conditions relies on the mobilization of stem cells and partially differentiated progenitor cells. Bone marrow transplantation studies have demonstrated that medullary hematopoietic and endothelial progenitors can undergo mobilization and trafficking. While the ability of the bone marrow to boost its resources in fighting disease or repairing injury declines with age, other organs have surfaced as reservoirs of various progenitor cell populations. This chapter discusses our current understanding of non-bone marrow-derived progenitor pools, focusing on mesenchymal stem cells. The evidence for the extramedullary progenitor mobilization, with a specific emphasis on white adipose tissue, is presented.
各种病理状况的病程依赖于干细胞和部分分化祖细胞的动员。骨髓移植研究表明，骨髓造血祖细胞和内皮祖细胞能够发生动员和迁移。虽然骨髓在对抗疾病或修复损伤时增加其资源的能力会随着年龄增长而下降，但其他器官已成为各种祖细胞群体的储备库。本章讨论了我们目前对非骨髓来源祖细胞库的理解，重点是间充质干细胞。文中呈现了关于髓外祖细胞动员的证据，特别强调了白色脂肪组织。
