2 Gaston Cottages, Bookham, Surrey, UK (formerly St George's Hospital, London, UK).
J Appl Res Intellect Disabil. 2012 Sep;25(5):414-22. doi: 10.1111/j.1468-3148.2011.00676.x. Epub 2012 Jan 26.
A population sample of people with Down Syndrome, repeatedly studied since infancy, has now been followed up at the age of 45 years. The paper is intended to give an overview of their abilities, as represented by the results of psychological tests, over their life span to date.
As at all previous occasions from age 30 onwards, intelligence, language, academic abilities and memory were tested, and self-help skills assessed.
Mean IQs, both non-verbal and verbal, changed little from age 21 to 45. Disregarding the scores of two women severely affected by dementia, the remainder of the cohort lost over the whole period an average of less than one point in non-verbal IQ and gained over five months in verbal age. Scores on memory tests by some of those not yet diagnosed with AD declined, in some cases significantly, suggesting that other members of the cohort too may be showing the early signs of the disease.
While most of the cohort show few indications of decline in ability, a number now are or may be affected by AD, and this may require closer monitoring in the future.
一个自婴儿期起就被反复研究的唐氏综合征人群样本，现已在 45 岁时进行了随访。本文旨在概述他们迄今为止在整个生命周期中通过心理测试所表现出的能力。
与以往所有 30 岁以后的情况一样，对智力、语言、学术能力和记忆力进行了测试，并评估了自理能力。
非言语和言语平均智商从 21 岁到 45 岁变化不大。不考虑两名受痴呆症严重影响的女性的分数，其余队列在整个期间平均非言语智商下降不到 1 分，言语年龄增加超过 5 个月。一些尚未被诊断为 AD 的人的记忆测试分数下降，在某些情况下下降明显，这表明队列中的其他成员也可能出现了该疾病的早期迹象。
尽管大多数队列显示出能力下降的迹象很少，但现在有一些人或可能受到 AD 的影响，这可能需要在未来进行更密切的监测。
