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Monoclonal antibody-based therapies: a new dawn in the treatment of acute lymphoblastic leukemia.

作者信息

Kantarjian Hagop, Thomas Deborah, Wayne Alan S, O'Brien Susan

机构信息

Leukemia Department, MD Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX 77030, USA.

出版信息

J Clin Oncol. 2012 Nov 1;30(31):3876-83. doi: 10.1200/JCO.2012.41.6768. Epub 2012 Aug 13.

DOI:10.1200/JCO.2012.41.6768
PMID:22891271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3478578/
Abstract
摘要

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Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.抗CD22免疫毒素莫克妥昔单抗帕苏妥昔用于儿童急性淋巴细胞白血病的1期研究。
Blood. 2017 Oct 5;130(14):1620-1627. doi: 10.1182/blood-2017-02-749101. Epub 2017 Aug 9.
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Re-induction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL): Phase II results from Children's Oncology Group (COG) study ADVL04P2.复发急性淋巴细胞白血病(ALL)中再次使用依鲁替尼化疗免疫治疗:来自儿童肿瘤学组(COG)ADVL04P2 研究的 II 期结果。
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Improved efficacy using rituximab and brief duration, high intensity chemotherapy with filgrastim support for Burkitt or aggressive lymphomas: cancer and Leukemia Group B study 10 002.美罗华联合短程、高强度化疗联合粒细胞集落刺激因子支持治疗伯基特或侵袭性淋巴瘤的疗效改善:癌症和白血病组 B 研究 10002。
Br J Haematol. 2014 Apr;165(1):102-11. doi: 10.1111/bjh.12736. Epub 2014 Jan 15.
4
Phase I multidose-escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous infusion every 3 weeks to patients with relapsed/refractory B-cell lymphoma.一项抗 CD19 美登素免疫偶联物 SAR3419 的 I 期多剂量递增研究,该药物通过静脉输注给药,每 3 周给药一次,用于治疗复发/难治性 B 细胞淋巴瘤患者。
J Clin Oncol. 2012 Aug 1;30(22):2776-82. doi: 10.1200/JCO.2011.39.4403. Epub 2012 Jul 2.
5
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.急性淋巴细胞白血病伴分子学复发的成年患者预后不良,是干细胞移植和靶向治疗的候选人群。
Blood. 2012 Aug 30;120(9):1868-76. doi: 10.1182/blood-2011-09-377713. Epub 2012 Mar 22.
6
Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study.依妥珠单抗奥滨尤妥珠单抗,一种抗 CD22-卡利霉素偶联物,用于治疗难治和复发的急性淋巴细胞白血病:一项 2 期研究。
Lancet Oncol. 2012 Apr;13(4):403-11. doi: 10.1016/S1470-2045(11)70386-2. Epub 2012 Feb 21.
7
SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies.SAR3419:一种抗 CD19-美登素免疫偶联物,用于治疗 B 细胞恶性肿瘤。
Clin Cancer Res. 2011 Oct 15;17(20):6448-58. doi: 10.1158/1078-0432.CCR-11-0485.
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Antibody-drug conjugates of calicheamicin derivative: gemtuzumab ozogamicin and inotuzumab ozogamicin.加利车霉素衍生物抗体药物偶联物:吉妥珠单抗奥佐米星和伊妥珠单抗奥佐米星。
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Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox.抗体融合蛋白:抗 CD22 重组免疫毒素 moxetumomab pasudotox。
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Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.免疫毒素和抗体药物偶联物治疗血液系统恶性肿瘤。
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