Rysakova M P, Pavlova I V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 May-Jun;62(3):332-45.
The effects of right-side or left-side intra-amygdala injections of the GABA(A)-receptor agonist muscimol hydrobromide (0.1 microg/1 microl) and antagonist bicuculline methiodide (0.05, 0.1, 0.5 microg/1 microl) on the behavior of active and passive rabbits were studied in open field, light-dark test and during presentation of emotionally significant stimuli. The effect of compounds injection was differed in active and passive rabbits. The active rabbits were more sensitive to bicuculline injection and the passive rabbits to muscimol administration. Bicuculline induced anxiolytic-like effects on the active animals in open field, light-dark test and motor-activating effects during emotionally significant stimuli. Muscimol induced anxiolytic-like effects on the passive rabbits and sedative effects on the both groups of rabbits. The differences in effectiveness of right-side and left-side intra-amygdala injections on behavior of rabbits were revealed: more powerful changes were during injection of bicuculline in left and muscimol in right amygdala. Anxiolytic-like effects were revealed during injection of bicuculline into left amygdala of active rabbits and muscimol into right amygdala of passive rabbits. These findings indicate that there are individual-typological and interhemispheric differences in functioning of GABAergic system of amygdala.
研究了向兔杏仁核右侧或左侧注射γ-氨基丁酸A（GABA(A)）受体激动剂氢溴酸蝇蕈醇（0.1微克/1微升）和拮抗剂甲碘化荷包牡丹碱（0.05、0.1、0.5微克/1微升）对主动和被动兔在旷场试验、明暗试验以及呈现情绪性显著刺激期间行为的影响。化合物注射的效果在主动兔和被动兔中有所不同。主动兔对荷包牡丹碱注射更敏感，而被动兔对蝇蕈醇给药更敏感。荷包牡丹碱在旷场试验和明暗试验中对主动动物诱导出类似抗焦虑的作用，在情绪性显著刺激期间诱导出运动激活作用。蝇蕈醇对被动兔诱导出类似抗焦虑的作用，对两组兔均诱导出镇静作用。揭示了右侧和左侧杏仁核内注射对兔行为影响的有效性差异：在左侧注射荷包牡丹碱和右侧注射蝇蕈醇时变化更强烈。在向主动兔左侧杏仁核注射荷包牡丹碱和向被动兔右侧杏仁核注射蝇蕈醇期间发现了类似抗焦虑的作用。这些发现表明杏仁核GABA能系统的功能存在个体类型和半球间差异。
