Perisanidis C, Savarese-Brenner B, Würger T, Wrba F, Huynh A, Schopper C, Kornek G, Selzer E, Ewers R, Psyrri A, Krainer M, Filipits M
Departments of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria.
Oral Dis. 2013 Mar;19(2):206-11. doi: 10.1111/j.1601-0825.2012.01972.x. Epub 2012 Aug 14.
The hepatocellular carcinoma-related protein 1 (HCRP1) is a key factor in the degradation of the epidermal growth factor receptor. In this study, we assessed the prognostic significance of HCRP1 expression in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).
HCRP1 expression was determined by immunohistochemistry on tissue biopsy sections of 111 patients with locally advanced OOSCC undergoing neoadjuvant chemoradiotherapy followed by surgery. The Kaplan-Meier method and Cox regression models were used for survival analyses.
Low HCRP1 expression was associated with poor recurrence-free survival (P = 0.046) and overall survival (P = 0.03). Multivariate analysis revealed that low HCRP1 expression remained an independent risk factor for relapse (HR 2.98, 95% CI 1.19-7.49, P = 0.02) and death (HR 3.04, 95% CI 1.19-7.79, P = 0.02).
Low HCRP1 expression was found to be of adverse prognostic significance in patients with OOSCC who received preoperative chemoradiotherapy.
肝细胞癌相关蛋白1（HCRP1）是表皮生长因子受体降解的关键因素。在本研究中，我们评估了HCRP1表达在口腔和口咽鳞状细胞癌（OOSCC）患者中的预后意义。
通过免疫组织化学法检测111例接受新辅助放化疗后手术的局部晚期OOSCC患者组织活检切片中的HCRP1表达。采用Kaplan-Meier法和Cox回归模型进行生存分析。
HCRP1低表达与无复发生存期差（P = 0.046）和总生存期差（P = 0.03）相关。多变量分析显示，HCRP1低表达仍然是复发（HR 2.98，95%CI 1.19 - 7.49，P = 0.02）和死亡（HR 3.04，95%CI 1.19 - 7.79，P = 0.02）的独立危险因素。
在接受术前放化疗的OOSCC患者中，HCRP1低表达具有不良预后意义。
