Fernández Casares Marcelo, González Alejandra, Caputo Flavia, Bottinelli Yanina, Nastavi Patricia, Zamboni Marcelo
Sección Neumonología, Hospital Profesor Alejandro Posadas, Haedo, Buenos Aires, Argentina.
Medicina (B Aires). 2012;72(4):329-31.
The most frequently observed pulmonary complications of vasculitis (AAV) with anti-neutrophil cytoplasmic positive antibodies (ANCA) are alveolar hemorrhage, granulomas and airway stenosis. In recent years, some reports have been published that show the association of vasculitis with pulmonary fibrosis (PF), suggesting that it may be another complication of AAV. We report and describe here two cases with such association, and their clinical, tomographic and immunological characteristics. Given that in the association between PF and AAV, as reported in the last years, PF could be the first manifestation of AAV, the search for ANCA in patients with PF may be necessary, as a cause of it and for the possible subsequent development of vasculitis.
抗中性粒细胞胞浆抗体（ANCA）阳性的血管炎（AAV）最常观察到的肺部并发症是肺泡出血、肉芽肿和气道狭窄。近年来，有一些报告表明血管炎与肺纤维化（PF）有关联，提示这可能是AAV的另一种并发症。我们在此报告并描述两例有这种关联的病例及其临床、影像学和免疫学特征。鉴于近年来报道的PF与AAV的关联中，PF可能是AAV的首发表现，因此对PF患者进行ANCA检测可能是必要的，既可作为其病因，也可用于监测血管炎可能的后续发展。
