利用铁载体摄取机制的新型单环β-内酰胺类抗生素，用于治疗革兰氏阴性感染。
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
机构信息
Medicinal Chemistry, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA.
出版信息
Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. doi: 10.1016/j.bmcl.2012.07.005. Epub 2012 Jul 20.
PMID:22892121
Abstract
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
摘要
描述了具有体外和体内抗多药耐药革兰氏阴性病原体抗菌活性的新型铁载体连接的单环β-内酰胺类抗生素。
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