Loma Linda University, School of Dentistry, Dept of Restorative Dentistry, Loma Linda, CA 92354, USA.
J Dent. 2012 Nov;40(11):955-61. doi: 10.1016/j.jdent.2012.08.001. Epub 2012 Aug 11.
The purpose of this study was to consider the impact of surface defects on quantitative light-induced fluorescence (QLF) and micro-digital-photography (MDP) measures, in relationship to lesion depth.
Simulated enamel carious lesions were developed on 45 extracted human teeth. Images of each tooth were captured with both QLF and MDP. The teeth were sectioned and lesion depth was measured with polarized light microscopy (PLM). Pearson correlations were computed using data from the 27 lesions which did not have surface loss, and then separately based upon the 18 lesions which did display surface loss. MDP variables ΔR and ΔX measure reflected light, whereas QLF variables ΔF and ΔQ measure fluorescence.
A strong correlation was identified between lesion depth and ΔF (r=-0.765, p<0.0001), and ΔQ (r=-0.827, p<0.0001) on intact lesions while a weak but suggestive, although non-significant, correlation was identified between average lesion depth and ΔR (r=0.369, p=0.059) and ΔX (r=0.595, p=0.0011). However, the corresponding correlation was not statistically significant, when lesions with surface loss were considered for QLF and MDP measures.
QLF measures ΔF and ΔQ were strongly correlated with lesion depth in lab-simulated lesions with no surface loss, but not among lesions with surface defects. The two MDP-associated measures, ΔR and ΔX, could not be said to differ significantly when lesions with and without surface defects were compared with lesion depth. Because intact lesions can be remineralized, accurate assessment of their status is imperative for caries treatment.
Dental caries is still widely prevalent today. We now know that with early stage detection, remineralization can be accomplished. Being able to identify dental caries in its reversible stage (before physical surface loss) is paramount for the clinician to be able to treat the disease non-invasively.
本研究旨在探讨表面缺陷对定量光诱导荧光（QLF）和微数字摄影（MDP）测量值的影响，以及与病变深度的关系。
在 45 颗离体人牙上制作模拟釉质龋损。用 QLF 和 MDP 对每颗牙进行成像。用偏光显微镜（PLM）测量牙齿的切片和病变深度。对没有表面损失的 27 个病变进行 Pearson 相关性计算，然后根据有表面损失的 18 个病变分别进行计算。MDP 变量 ΔR 和 ΔX 测量反射光，而 QLF 变量 ΔF 和 ΔQ 测量荧光。
在完整的病变中，病变深度与 ΔF（r=-0.765，p<0.0001）和 ΔQ（r=-0.827，p<0.0001）之间存在很强的相关性，而在平均病变深度与 ΔR（r=0.369，p=0.059）和 ΔX（r=0.595，p=0.0011）之间存在弱但提示性的相关性，但无统计学意义。然而，当考虑有表面损失的病变时，QLF 和 MDP 测量值的相关性没有统计学意义。
在没有表面损失的实验室模拟病变中，QLF 测量值 ΔF 和 ΔQ 与病变深度呈强相关性，但在有表面缺陷的病变中无相关性。当比较有和无表面缺陷的病变与病变深度时，两个与 MDP 相关的测量值 ΔR 和 ΔX 不能说有显著差异。由于完整的病变可以再矿化，因此对其状态进行准确评估对于龋齿治疗至关重要。
牙病至今仍广泛流行。现在我们知道，早期发现可以实现再矿化。临床医生能够在龋齿处于可逆转阶段（在物理表面损失之前）识别出龋齿，这对于能够对疾病进行非侵入性治疗至关重要。
