Kishi Seiji, Yamada Satoshi, Kishi Fumi, Shibata Eriko, Matsuura Motokazu, Nagai Kojiro, Mima Akira, Abe Hideharu, Doi Toshio
Department of Nephrology, Tokushima University Hospital, Japan.
Intern Med. 2012;51(16):2197-201. doi: 10.2169/internalmedicine.51.7919. Epub 2012 Aug 15.
The prevalence of postinfectious glomerulonephritis has decreased in most developed countries. We report the case of a previously healthy, immunocompetent 65-year-old woman who developed acute glomerulonephritis associated with human parvovirus B19 infection. She was referred by her primary care physician for suspected congestive heart failure but she had an elevated creatinine level and an abnormal urinalysis. Renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. After biopsy, we learned that she had been in frequent contact with her grandson who had been diagnosed with erythema infectiosum. Her human parvovirus B19 serum IgM titer was elevated at 3.50, indicating current infection.
在大多数发达国家，感染后肾小球肾炎的发病率已有所下降。我们报告了一例病例，一名65岁既往健康、免疫功能正常的女性患上了与人类细小病毒B19感染相关的急性肾小球肾炎。她因疑似充血性心力衰竭被初级保健医生转诊，但肌酐水平升高且尿液分析异常。肾活检显示弥漫性毛细血管内增生性肾小球肾炎。活检后，我们了解到她经常与被诊断为传染性红斑的孙子接触。她的人类细小病毒B19血清IgM滴度升高至3.50，表明目前存在感染。
