Universität Heidelberg, Anorganisch-Chemisches Institut, INF 270, D-69120 Heidelberg, Germany.
Chem Commun (Camb). 2012 Sep 28;48(75):9364-6. doi: 10.1039/c2cc34836e. Epub 2012 Aug 15.
A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu(2)(H(2)Pat(1))(μ-OH)(OH(2))(2)]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO(2) into CO(3)(2-). This complex is shown here to function as a phosphatase mimic, suggesting that the so far unknown biological function of these macrocycles within the ascidians may involve phosphoester hydrolysis.
提出了环状拟八肽的一种可能的生物学功能。天然存在的海鞘环肽的合成类似物（[Cu（2）（H 2 Pat（1））（μ-OH）（OH 2 ）（2）]）的双核铜（II）配合物已知具有羟桥双核铜（II）位点，能够催化 CO 2 转化为 CO 3 （2-）。本文表明，该配合物可作为磷酸酶模拟物发挥作用，这表明目前在海鞘中这些大环内酯的未知生物学功能可能涉及磷酸酯水解。
