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[直肠癌的当前MRI分期]

[Current MRI staging of rectal cancer].

作者信息

Wietek B M, Kratt T

机构信息

Abt. f. Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Tübingen, Germany.

出版信息

Rofo. 2012 Nov;184(11):992-1001. doi: 10.1055/s-0032-1313051. Epub 2012 Aug 14.

DOI:10.1055/s-0032-1313051
PMID:22893486
Abstract

Colorectal carcinoma is the second most prevalent cause for cancer, and has very variable outcomes. Advancements in surgery, the change from adjuvant to neo-adjuvant radio-chemo-therapies as well as in clinical diagnostics have improved the prognosis for patients in a multi-modal therapy concept. An accurate primary staging including a reliable prediction of the circumferential resection margin (CRM) has established MR Imaging (MRI) beside intraluminal endoscopic ultrasound (EUS). MRI facilitates the selection of patients likely to benefit from a preoperative therapy, especially in cases of unfavorable factors. Currently the relationship of the tumor to the mesorectal fascia has become a more important prognostic factor than the T-staging, particularly for surgical therapy. In addition further prognostic factors like the depth of infiltration into the perirectal fat and the extramural venous infiltration (EMVI) have important impact on therapy and prognosis. High resolution MRI has proved useful in clarifying the relationship between the tumor and the mesorectal fascia, which represents the CRM at the total mesorectal excision (TME) especially in the upper and middle third. Preoperative evaluation of the other prognostic factors as well as the nodal status is still difficult. It is used increasingly not only for primary staging but also progressively for the monitoring of neoadjuvant therapy. The addition of diffusion weighted imaging (DWI) is an interesting option for the improvement of response evaluation. The following overview provides an introduction of MRI diagnosis as well as its importance for the evaluation of the clinically relevant prognostic factors leading to an improvement of therapy and prognosis of patients with rectal carcinoma.

摘要

结直肠癌是第二大常见癌症病因,其预后差异很大。手术技术的进步、辅助放化疗向新辅助放化疗的转变以及临床诊断方面的进展,在多模式治疗理念下改善了患者的预后。除腔内超声内镜(EUS)外,包括对环周切缘(CRM)进行可靠预测的准确原发灶分期已确立了磁共振成像(MRI)的地位。MRI有助于筛选可能从术前治疗中获益的患者,尤其是存在不利因素的病例。目前,肿瘤与直肠系膜筋膜的关系已成为比T分期更重要的预后因素,特别是在手术治疗方面。此外,诸如肿瘤浸润直肠周围脂肪的深度和壁外静脉浸润(EMVI)等其他预后因素对治疗和预后也有重要影响。高分辨率MRI已被证明有助于明确肿瘤与直肠系膜筋膜之间的关系,而直肠系膜筋膜在直肠全系膜切除(TME)中代表CRM,尤其是在中上部。术前评估其他预后因素以及淋巴结状态仍然困难。MRI不仅越来越多地用于原发灶分期,还逐渐用于新辅助治疗的监测。添加扩散加权成像(DWI)是改善疗效评估的一个有趣选择。以下综述介绍了MRI诊断及其对评估临床相关预后因素的重要性,这有助于改善直肠癌患者的治疗和预后。

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1
[Current MRI staging of rectal cancer].[直肠癌的当前MRI分期]
Rofo. 2012 Nov;184(11):992-1001. doi: 10.1055/s-0032-1313051. Epub 2012 Aug 14.
2
[Accuracy of preoperative magnetic resonance imaging in prediction of pathological stage and circumferential resection margin in rectal cancer].[术前磁共振成像在预测直肠癌病理分期及环周切缘中的准确性]
Zhonghua Yi Xue Za Zhi. 2006 Apr 11;86(14):961-4.
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Br J Surg. 2003 Mar;90(3):355-64. doi: 10.1002/bjs.4034.
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MR evaluation of rectal cancer: current concepts.直肠癌的磁共振成像评估:当前概念
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Preoperative staging of rectal cancer with MR Imaging: correlation with surgical and histopathologic findings.直肠癌的磁共振成像术前分期:与手术及组织病理学结果的相关性
Radiographics. 2006 May-Jun;26(3):701-14. doi: 10.1148/rg.263055086.
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Diffusion-weighted MRI in rectal cancer: apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness.直肠癌的弥散加权 MRI:表观弥散系数作为肿瘤侵袭性的潜在无创标志物。
J Magn Reson Imaging. 2012 Jun;35(6):1365-71. doi: 10.1002/jmri.23589. Epub 2012 Jan 23.
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Diagn Interv Imaging. 2014 May;95(5):495-503. doi: 10.1016/j.diii.2014.03.010. Epub 2014 Apr 22.
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Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumor-free circumferential resection margins and long-term survival.直肠癌:新辅助化疗和放疗前的磁共振成像用于预测环周切缘无肿瘤及长期生存情况
Radiology. 2007 Jun;243(3):744-51. doi: 10.1148/radiol.2433060421. Epub 2007 Apr 26.
10
Endorectal coil MRI in local staging of rectal cancer.直肠内线圈磁共振成像在直肠癌局部分期中的应用
Radiol Med. 2002 Jan-Feb;103(1-2):74-83.

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