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Human papillomavirus vaccine delivery strategies that achieved high coverage in low- and middle-income countries.在中低收入国家实现高覆盖率的人乳头瘤病毒疫苗接种策略。
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Success of HPV vaccination is now a matter of coverage.人乳头瘤病毒疫苗接种的成功现在取决于接种覆盖率。
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Making new vaccines affordable: a comparison of financing processes used to develop and deploy new meningococcal and pneumococcal conjugate vaccines.使新疫苗负担得起:比较开发和部署新脑膜炎球菌和肺炎球菌结合疫苗所使用的融资流程。
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在卢旺达国家人乳头瘤病毒疫苗接种计划中实现高覆盖率。

Achieving high coverage in Rwanda's national human papillomavirus vaccination programme.

机构信息

Ministry of Health, Kigali, Rwanda.

出版信息

Bull World Health Organ. 2012 Aug 1;90(8):623-8. doi: 10.2471/BLT.11.097253. Epub 2012 May 23.

DOI:10.2471/BLT.11.097253
PMID:22893746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3417784/
Abstract

PROBLEM

Virtually all women who have cervical cancer are infected with the human papillomavirus (HPV). Of the 275,000 women who die from cervical cancer every year, 88% live in developing countries. Two vaccines against the HPV have been approved. However, vaccine implementation in low-income countries tends to lag behind implementation in high-income countries by 15 to 20 years.

APPROACH

In 2011, Rwanda's Ministry of Health partnered with Merck to offer the Gardasil HPV vaccine to all girls of appropriate age. The Ministry formed a "public-private community partnership" to ensure effective and equitable delivery.

LOCAL SETTING

Thanks to a strong national focus on health systems strengthening, more than 90% of all Rwandan infants aged 12-23 months receive all basic immunizations recommended by the World Health Organization.

RELEVANT CHANGES

In 2011, Rwanda's HPV vaccination programme achieved 93.23% coverage after the first three-dose course of vaccination among girls in grade six. This was made possible through school-based vaccination and community involvement in identifying girls absent from or not enrolled in school. A nationwide sensitization campaign preceded delivery of the first dose.

LESSONS LEARNT

Through a series of innovative partnerships, Rwanda reduced the historical two-decade gap in vaccine introduction between high- and low-income countries to just five years. High coverage rates were achieved due to a delivery strategy that built on Rwanda's strong vaccination system and human resources framework. Following the GAVI Alliance's decision to begin financing HPV vaccination, Rwanda's example should motivate other countries to explore universal HPV vaccine coverage, although implementation must be tailored to the local context.

摘要

问题

几乎所有患有宫颈癌的女性都感染了人乳头瘤病毒(HPV)。在每年因宫颈癌而死亡的 27.5 万名女性中,88%生活在发展中国家。已经批准了两种针对 HPV 的疫苗。然而,低收入国家的疫苗接种实施往往滞后于高收入国家 15 至 20 年。

方法

2011 年,卢旺达卫生部与默克公司合作,向所有适龄女孩提供 Gardasil HPV 疫苗。该部建立了“公私社区伙伴关系”,以确保有效和公平的提供疫苗。

当地背景

由于国家高度重视加强卫生系统,卢旺达 90%以上的 12-23 个月龄婴儿都接受了世界卫生组织推荐的所有基本免疫接种。

相关变化

在 2011 年,卢旺达的 HPV 疫苗接种计划在六年级女孩中完成了前三剂疫苗接种后,覆盖率达到了 93.23%。这是通过在学校接种疫苗和社区参与确定未上学或未注册的女孩来实现的。在接种第一剂疫苗之前,进行了全国性的宣传运动。

经验教训

通过一系列创新的伙伴关系,卢旺达将高收入和低收入国家在疫苗引入方面的历史 20 年差距缩小到仅仅 5 年。高覆盖率是由于一种基于卢旺达强大的疫苗接种系统和人力资源框架的交付策略实现的。在全球疫苗免疫联盟决定开始资助 HPV 疫苗接种之后,卢旺达的例子应该激励其他国家探索普遍的 HPV 疫苗接种覆盖范围,尽管实施必须根据当地情况进行调整。