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通过重组乳酸菌免疫预防沙门氏菌感染

[Protection against Salmonella via immunization with recombinant lactic acid bacteria].

作者信息

Kajikawa Akinobu

机构信息

Department of Microbiology, Immunology, and Pathology, Colorado State University.

出版信息

Nihon Rinsho. 2012 Aug;70(8):1293-7.

Abstract

Mucosal immunization of hens may be effective to prevent contamination of Salmonella enterica serovar Enteritidis (SE) in eggs. Lactic acid bacteria have been considered potential vaccine delivery agents because they are safe, immunogenic, and inexpensive. Our research group has been investigating the development of oral vaccines against SE using a Lactobacillus casei strain as an antigen delivery vehicle. Recombinant lactobacilli expressing SE antigens FliC and SipC have been constructed and administered to mice. Antigen specific immune responses and protective immunity were elicited after the immunization. For adjuvant delivery, IL-1beta-secreting L. casei was also engineered and its efficacies were evaluated in vitro and in vivo. This article reviews a novel approach to develop SE vaccines using recombinant lactobacilli.

摘要

对母鸡进行黏膜免疫可能有助于预防鸡蛋被肠炎沙门氏菌(SE)污染。乳酸菌因其安全、具有免疫原性且成本低廉,被认为是潜在的疫苗递送载体。我们的研究小组一直在研究以干酪乳杆菌菌株作为抗原递送载体开发针对SE的口服疫苗。已构建表达SE抗原FliC和SipC的重组乳杆菌并将其接种给小鼠。免疫后引发了抗原特异性免疫反应和保护性免疫。为了递送佐剂,还构建了分泌IL-1β的干酪乳杆菌,并在体外和体内评估了其效果。本文综述了一种使用重组乳杆菌开发SE疫苗的新方法。

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