Kumar Manoj, Sarma Devojit Kumar, Shubham Swasti, Kumawat Manoj, Verma Vinod, Nina Praveen Balabaskaran, Jp Devraj, Kumar Santosh, Singh Birbal, Tiwari Rajnarayan R
ICMR-National Institute for Research in Environmental Health, Bhopal, India.
Stem Cell Research Centre, Department of Hematology, SGPGIMS, Lucknow, India.
Front Microbiol. 2021 Jan 26;12:609459. doi: 10.3389/fmicb.2021.609459. eCollection 2021.
The looming problem of resistance to antibiotics in microorganisms is a global health concern. The drug-resistant microorganisms originating from anthropogenic sources and commercial livestock farming have posed serious environmental and health challenges. Antibiotic-resistant genes constituting the environmental "resistome" get transferred to human and veterinary pathogens. Hence, deciphering the origin, mechanism and extreme of transfer of these genetic factors into pathogens is extremely important to develop not only the therapeutic interventions to curtail the infections, but also the strategies to avert the menace of microbial drug-resistance. Clinicians, researchers and policymakers should jointly come up to develop the strategies to prevent superfluous exposure of pathogens to antibiotics in non-clinical settings. This article highlights the present scenario of increasing antimicrobial-resistance in pathogenic bacteria and the clinical importance of unconventional or non-antibiotic therapies to thwart the infectious pathogenic microorganisms.
微生物对抗生素耐药这一迫在眉睫的问题是全球卫生关注的焦点。源自人为来源和商业畜牧业的耐药微生物带来了严峻的环境和健康挑战。构成环境“耐药基因组”的抗生素耐药基因会转移到人类和兽用病原体中。因此，不仅要弄清楚这些遗传因素转移到病原体中的起源、机制和程度，对于开发减少感染的治疗干预措施，而且对于制定避免微生物耐药威胁的策略都极为重要。临床医生、研究人员和政策制定者应共同努力制定策略，以防止病原体在非临床环境中过度接触抗生素。本文重点介绍了病原菌中抗菌耐药性增加的现状，以及非常规或非抗生素疗法在对抗感染性致病微生物方面的临床重要性。
