Reinhardt S, Hillbrand M, Wilkens J J, Assmann W
Fakultät für Physik, Ludwig-Maximilians Universität München, 85748 Garching, Germany.
Med Phys. 2012 Aug;39(8):5257-62. doi: 10.1118/1.4737890.
Dose verification in highly conformal radiation therapy such as IMRT or proton therapy can benefit from the high spatial resolution offered by radio-chromic films such as Gafchromic EBT or EBT2. Recently, a new generation of these films, EBT3, has become available. The composition and thickness of the sensitive layer are the same as for the previous EBT2 films. The most important change is the symmetric layer configuration to eliminate side orientation dependence, which is reported for EBT2 films.
The general film characteristics such as sensitivity to read-out orientation and postexposure darkening evolution of the new EBT3 film are evaluated. Film response has been investigated in clinical photon and proton beams and compared to former EBT2 films. Quenching effects in the proton Bragg peak region have been studied for both, EBT2 and EBT3 films.
The general performance of EBT3 is comparable to EBT2, and the orientation dependence with respect to film side is completely eliminated in EBT3 films. Response differences of EBT2 and EBT3 films are of the same order of magnitude as batch-to-batch variations observed for EBT2 films. No significant difference has been found for both generations of EBT films between photon and proton exposure. Depth dose measurements of EBT2 and EBT3 show an excellent agreement, though underestimating dose by up to 20% in the Bragg peak region.
The symmetric configuration of EBT3 presents a major improvement for film handling. EBT3 has similar dosimetric performance as its precursor EBT2 and can, thus, be applied to dose verification in IMRT in the same way. For dose verification in proton therapy the underresponse in the Bragg peak region has to be taken into account.
在诸如调强放射治疗(IMRT)或质子治疗等高适形放射治疗中进行剂量验证时,可受益于如Gafchromic EBT或EBT2等放射变色胶片所提供的高空间分辨率。最近,新一代的此类胶片EBT3已面市。敏感层的成分和厚度与之前的EBT2胶片相同。最重要的变化是对称层结构,以消除EBT2胶片所存在的侧方向依赖性。
评估了新EBT3胶片的一般胶片特性,如对读出方向的敏感性和照射后暗化演变。已在临床光子束和质子束中研究了胶片响应,并与之前的EBT2胶片进行了比较。对EBT2和EBT3胶片在质子布拉格峰区域的猝灭效应均进行了研究。
EBT3的总体性能与EBT2相当,且EBT3胶片完全消除了与胶片侧面有关的方向依赖性。EBT2和EBT3胶片的响应差异与EBT2胶片批次间变化的量级相同。两代EBT胶片在光子和质子照射之间均未发现显著差异。EBT2和EBT3的深度剂量测量结果显示出极佳的一致性,不过在布拉格峰区域剂量低估高达20%。
EBT3的对称结构在胶片处理方面有重大改进。EBT3具有与其前身EBT2相似的剂量学性能,因此可同样应用于IMRT中的剂量验证。对于质子治疗中的剂量验证,必须考虑布拉格峰区域的响应不足。