血小板活化因子诱导的豚鼠离体气管舒张是上皮依赖性的，并被WEB 2086拮抗。

Relaxations of guinea-pig isolated trachea induced by platelet-activating factor are epithelial-dependent and are antagonised by WEB 2086.

作者信息

Conroy D M, Samhoun M N, Piper P J

机构信息

Department of Pharmacology, Hunterian Institute, Royal College of Surgeons of England, U.K.

出版信息

Eur J Pharmacol. 1990 Sep 21;186(2-3):315-8. doi: 10.1016/0014-2999(90)90451-b.

DOI:10.1016/0014-2999(90)90451-b

PMID:2289533

Abstract

Platelet-activating factor (PAF, 10-1000 pmol) induced dose-dependent relaxations of the basal tone of superfused strips of epithelium-intact guinea-pig trachea. Indomethacin (1.4 microM) completely inhibited and WEB 2086 (1 and 10 nM) effectively antagonised these relaxations. Following epithelial removal PAF evoked a single contraction. These results show that the PAF-induced relaxations of guinea-pig trachea are dependent on an intact epithelial layer and are mediated by a cyclo-oxygenase product.

摘要

血小板活化因子（PAF，10 - 1000皮摩尔）可引起豚鼠完整上皮气管灌流条基础张力呈剂量依赖性舒张。吲哚美辛（1.4微摩尔）可完全抑制，而WEB 2086（1和10纳摩尔）可有效拮抗这些舒张反应。去除上皮后，PAF引起单次收缩。这些结果表明，PAF诱导的豚鼠气管舒张依赖于完整的上皮层，且由环氧化酶产物介导。