Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Nat Rev Mol Cell Biol. 2012 Sep;13(9):591-600. doi: 10.1038/nrm3416. Epub 2012 Aug 16.
The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.
细胞微环境的物理和机械特性调节细胞形状，并能强烈影响细胞命运。机械线索如何被感知和转导以调节基因表达，长期以来一直难以捉摸。最近，细胞外基质、细胞黏附位点、细胞形状和肌动球蛋白细胞骨架的线索被发现汇聚在 Hippo 通路下游效应物 YAP（Yes 相关蛋白）和 TAZ（具有 PDZ 结合基序的转录共激活因子）在脊椎动物和果蝇中的 Yorkie 的调节上。这种汇聚可能解释了机械信号如何指导正常和病理细胞行为。
