Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on.
作者信息
Riethmüller Gert
机构信息
Institute for Immunology, Ludwig-Maximilians-Universität, München, Germany.
出版信息
Cancer Immun. 2012;12:12. Epub 2012 May 1.
Abstract
摘要
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Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies.免疫球蛋白结构域交叉作为生产双特异性 IgG 抗体的通用方法。
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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.穿孔素在内涵体膜上形成孔道，触发内吞的颗粒酶 B 释放到靶细胞的细胞质中。
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Mechanism of immunoglobulin G4 Fab-arm exchange.免疫球蛋白 G4 Fab 臂交换的机制。
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Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.针对化疗耐药的 B 系急性淋巴细胞白血病患者微小残留病灶的 T 细胞结合抗体blinatumomab 的靶向治疗可带来高缓解率和延长无白血病生存。
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CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans.CTLA4 阻断诱导活化的淋巴细胞频繁浸润肿瘤，无论人类临床反应如何。
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Antibody-based therapeutics to watch in 2011.2011 年值得关注的抗体类药物治疗。
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Metrics for antibody therapeutics development.抗体治疗药物研发的评价指标。
MAbs. 2010 Nov-Dec;2(6):695-700. doi: 10.4161/mabs.2.6.13603. Epub 2010 Nov 1.
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