Tiurin V P, Serdiuk I E, Kushenko I P, Lashenkova N N, Gaĭdukova I A
Klin Med (Mosk). 2012;90(4):63-6.
Overcoming polyresistance of pathogens of infectious endocarditis (IE) is only possible through the use of new antibiotics, such as daptomycin, that was successfully used in 4 patients. The clinical features of endocarditis caused by Enterococcus faecalis resistant to penicillin, gentamicin, and streptomycin are described. Cases of IE with negative blood cultures and a failure of previous antibacterial therapy are considered. The literature data on the use of daptomycin in IE caused by oxacillin-resistant S. aureus are presented along with the information on valve prosthetics, peculiarities of IE in pregnant women and patients on hemodialysis.
只有通过使用新抗生素（如达托霉素，已成功应用于4例患者）才能克服感染性心内膜炎（IE）病原体的多重耐药性。本文描述了对青霉素、庆大霉素和链霉素耐药的粪肠球菌引起的心内膜炎的临床特征。还考虑了血培养阴性以及先前抗菌治疗失败的IE病例。文中呈现了关于达托霉素在耐苯唑西林金黄色葡萄球菌引起的IE中的应用的文献数据，以及瓣膜置换术、孕妇IE的特点和血液透析患者IE的相关信息。
